Nettet20. mai 2024 · The results showed that linezolid-associated myelosuppression occurs more frequently in patients with renal insufficiency, and the metabolite-to-parent concentration ratio of PNU-142300 is... Nettet15. des. 2003 · The oxazolidinone linezolid is indicated for treatment of serious infections caused by gram-positive cocci, including methicillin-resistant Staphylococcus aureus. In preclinical animal studies, reversible time- and dose-dependent myelosuppression occurred with administration of linezolid dosages of up to 1000 mg/kg/day for up to 3 …
Linezolid - an overview ScienceDirect Topics
Nettet15. mar. 2013 · However, reports of linezolid resistance in VRE have emerged, with an incidence as high as 20% . Moreover, prolonged treatment with linezolid can lead to myelosuppression, including neutropenia, thrombocytopenia, and anemia, which are frequent comorbid conditions already present in many patients with VRE infections (6, 10). Nettet7. aug. 2024 · It was rationally designed to address the myelosuppression and monoamine oxidase (MAO) inhibition limitations associated with linezolid . On 1 June 2024, contezolid was approved by the National Medical Products Administration of China for the treatment of complicated skin and soft tissue infections (cSSTI ... current gasoline prices in germany
A case of an 87-year-old woman with tuberculous pleurisy IDR
Nettet12. jun. 2024 · Linezolid is one of the most effective drugs for treating multidrug-resistant tuberculosis (MDR TB), but adverse effects remain problematic. We evaluated 57 MDR TB patients who had received > 1 dose of linezolid during 2011–2016. Overall, … Nettet3. nov. 2024 · Linezolid has became widely used alongside the increasing prevalence of multidrug-resistant bacteria. Linezolid is well tolerated, but myelosuppression in the form of thrombocytopenia and anaemia is a significant adverse drug reaction, of which thrombocytopenia has the highest risk. Nettet19. sep. 2024 · Severe myelosuppression occurred in both patients, with a severe decrease in leukocytes and platelets and a moderate decrease in hemoglobin, who eventually passed away despite the discontinuation of linezolid and adopting appropriate treatment measures. current gasoline prices around the world