Tīmeklis2016. gada 15. jūl. · Abstract Lysosome-associated membrane protein 1 (LAMP1) is involved in the maintenance of lysosome membrane integrity and phagolysosome formation. LAMP1 shows very limited expression at the cell surface in normal tissues while, a moderate to high expression was found in a number of solid tumors. Tīmeklis2024. gada 16. dec. · Introduction. The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is a major signaling pathway in various types of cancer. 1 It controls hallmarks of cancer, including cell survival ...
Targeting PI3K/Akt signal transduction for cancer therapy
Tīmeklis2024. gada 23. marts · Protein analysis of tumor samples excised from mice has further demonstrated that SDS-203 significantly enhanced the lysosomal marker protein LAMP1, indicating the role of SDS-203 mediated ... Tīmeklis2024. gada 22. sept. · The autophagy-related proteins AMPK, Raptor, mTOR, p62, LC3B, atg7, Rab7, LAMP1, LAMP2, and cathepsin D were detected by Immunoblotting. The antitumor effect of ARCSP was explored in vivo by establishing a transplant tumor model in nude mice. Results The results demonstrated that ARCSP induced cell … charlie\u0027s hair shop
LAMP1 expression is associated with poor prognosis in breast cancer
TīmeklisOverexpression of LAMP1 was observed in PCa and CRPC clinical specimens. Moreover, downstream pathways were identified using si-LAMP1-transfected cells. … Tīmeklis2024. gada 26. febr. · For instance, one study in breast cancer reports the presence of LAMP2, a LAMP1 homologous protein, at the PM of tumor cells located at the invasive front. These authors suggest that LAMP2 redistribution at the PM is an adaptive mechanism that allows cancer cells to survive in a harsh, acidic microenvironment by … TīmeklisIts 5-year survival rate remains very low. Lysosomal associated membrane proteins (LAMPs), including LAMP1 and LAMP2, are major protein components of the lysosome, which also plays an important role in tumor evolution. Our previous studies have confirmed that LAMP1 and LAMP2 play an important role in the evolution and … charlie\u0027s hardware mosinee