WebSt. Paul et al. show that FXR1 links mRNA processing with actin dynamics in vascular smooth muscle cells by binding to mRNAs and proteins that regulate the cytoskeleton. Deletion of FXR1 leads to decreased cellular migration, adhesion, and contraction. Additionally, mice without FXR1 have decreased blood pressure. WebApr 14, 2024 · Searching to explain certain pathogenic mechanisms associated with subependymal and subcortical heterotopia, the authors provide evidence that Dlgap4 interacts with proteins mediating VS integrity, influences the F-actin cytoskeleton, as 10 well as progenitor dynamics and proliferation.
Novel role of the synaptic scaffold protein dlgap4 in ventricular ...
WebMar 12, 2008 · Brouhard et al. (2008) showed that the Xenopus CKAP5 ortholog, Xmap215, functioned as a processive microtubule polymerase. Recombinant Xmap215 bound free porcine brain tubulin in a 1:1 complex that interacted with the microtubule lattice and targeted the ends by a diffusion-facilitated mechanism. Xmap215 persisted at the plus … Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene. It is the homolog of the Xenopus protein XMAP215 and is also known as ch-Tog. It has at least two distinct roles in spindle formation: it protects kinetochore microtubules from … See more CKAP5 has been shown to interact with TACC1. See more • Human CKAP5 genome location and CKAP5 gene details page in the UCSC Genome Browser. See more • Basto R, Gergely F, Draviam VM, Ohkura H, Liley K, Raff JW (2007). "Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans" See more how did the treaty versailles punish germany
Phosphorylation-dependent control of Activity-regulated cytoskeleton …
WebApr 12, 2024 · It is worth mentioning that HSP90 135, OSTF1 136, VDAC2 137, RPs 138,139, mitochondrial genes 140, Col2A1 141, and cytoskeleton-associated proteins 142,143,144, are all targets for MYC. WebGiven the importance of cytoskeleton for neurons, it is easy to see how neurological disorders involve changes either in the expression, dynamics, and and/or the stability of cytoskeletal proteins or their mutations. e.g. tauopathies, all share the common denominator of the altered structure or function of the microtubule-associated protein tau . WebMar 21, 2024 · CKAP2L (Cytoskeleton Associated Protein 2 Like) is a Protein Coding gene. Diseases associated with CKAP2L include Filippi Syndrome and Hypogonadism . Among its related pathways are 2q13 copy number variation syndrome . An important paralog of this gene is CKAP2. UniProtKB/Swiss-Prot Summary for CKAP2L Gene how did the triangle fire start