Cystatin domain
WebFeb 1, 2008 · The most characterized are mammalian cystatins, which were shown to regulate a broad range of physiological and pathological processes, including protein catabolism, hormone processing, bone... WebMar 18, 2011 · Tarocystatin (CeCPI) from taro (Colocasia esculenta cv. Kaohsiung no. 1), a group-2 phytocystatin, shares a conserved N-terminal cystatin domain (NtD) with other phytocystatins but contains a C-terminal cystatin-like extension (CtE). The structure of the tarocystatin–papain complex and the domain interaction between NtD and CtE in …
Cystatin domain
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WebJan 1, 2024 · The cystatins (CSTs) are secreted proteins 14- to 24-kDa in mass, which are distinguishable by a single cystatin domain, a typical signal peptide, and disulfide … WebJul 10, 2008 · A survey of cystatins and cysteine proteinases (C1A and C13) in plants. In a first step to know the origin and evolution of cystatins and papain and legumain-like cysteine proteinases in plants, an extensive search of the TIGR plant transcript assemblies (TA) database was made.
WebCystatin domain Provide feedback. Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. All members except Q03196 and Q10993 are found. PF00666 are related to this family but have not been included.
WebJul 10, 2008 · This carboxy terminal extensions are recognized by the Pfam motif database as a cystatin domain, which suggest that C-extensions of plant cystatins are degenerated parts of a dimeric cystatin that probably originated by gene duplication followed by divergent evolution. Curiously, a stop codon is located between the two domains of … WebNov 1, 1992 · In spite of the presence of cystatin domains, HSF does not inhibit cysteine proteinases such as papain and cathepsin B but does inhibit several metalloproteases in Habu venom. The results suggest that HSF is the first protein found to be functionally related to metalloproteinase inhibitors among the structurally homologous proteins with a ...
WebApr 4, 2024 · cystatin domain containing 5. Synonyms. BC100530 Feature Type. protein coding gene. IDs. MGI:3696883 NCBI Gene: 100034684. Alliance. gene page. Transcription Start Sites ... InterPro Domains. IPR000010 Cystatin domain. IPR046350 Cystatin superfamily. IPR001713 Proteinase inhibitor I25A, stefin. Molecular Reagents less. All …
WebMar 28, 2024 · cystatin domain containing 4. Synonyms. Gm5483 Feature Type. protein coding gene. IDs. MGI:3645124 NCBI Gene: 433016. Alliance. gene page. Transcription Start Sites. 1 TSS. Location & Maps more. Sequence Map Chr16:36004582-36008481 bp, + strand. From NCBI annotation of GRCm39 ... philosopher\\u0027s 2pWebThis cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. philosopher\\u0027s 2mWebOct 30, 2024 · This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. philosopher\u0027s 2nWebApr 1, 2001 · Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping. The crystal structure of human cystatin C, a protein with … philosopher\\u0027s 2rWebType 1 cystatins (stefins) are single domain proteins of about 100 amino acids, having no disulfide bonds, while type 2 cystatins are somewhat longer, about 120 amino acids, and have two internal disulfide bonds, kininogens are high molecular mass and multidomain glycoproteins ( Pavlova et al., 2000 ). philosopher\u0027s 2oWebPurpose: To test whether the cystatin-like functional domain in tear specific lipocalin (TSL) is functionally active in tears during the normal diurnal cycle and during external ocular infections. Methods: Capillary tube collected reflex (RTF), open (OTF) and closed (CTF) eye tear samples were recovered from six normals and semi-quantitatively western blot … philosopher\u0027s 2rWebNov 18, 2009 · The cystatin superfamily consists of a large group of cystatin domain-containing proteins, most of which are reversible and tight-binding inhibitors of the papain (C1) and legumain (C13) families of cysteine proteases [1–4].On the basis of sequence similarity, the presence or lack of disulfide bonds, and physiological localization, this … tshembo maluleke facebook